Igor Chudov has just published another review of a Science article that is worth the read as always:
At one point in the article, the authors speculate as to the cause of the “Long-Vax” symptoms they are tepidly admitting:
AN IMMUNE OVERREACTION to SARS-CoV-2 spike protein, which COVID-19 vaccines use to induce protective antibodies, is one possible cause of these symptoms. One theory is that after vaccination some people generate another round of antibodies targeting the first. Those antibodies could function somewhat like spike itself: Spike targets a cell surface protein called the angiotensin-converting enzyme 2 (ACE2) receptor, enabling the virus to enter cells. The rogue antibodies might also bind to ACE2, which helps regulate blood pressure and heart rate, says Bernhard Schieffer, a cardiologist at the University of Marburg. If those antibodies disrupt ACE2 signaling, that could cause the racing heart rates and blood pressure swings seen in POTS.
I find this curious. I haven’t heard or hypothesized about "rogue antibodies" being produced by the COVID shot that could ALSO bind to ACE2 receptors on cells (the COVID spike protein, however, was uniquely designed to do so).
The authors’ theory does not make much biological sense to me. That said, this is not my field so I'm open to learning (though I've done a LOT of reading and study of all of this in order to develop my own understanding of the mechanisms of action behind all of the various adverse reactions). I wonder if they are using this theory to explain why the neurological “Long-Vax” effects sometimes "lag" after vaccination.
I have understood the mechanism of action causing much of the tissue damage and neurological symptoms differently. I believe it is autoimmune, but occurs sometime after injection because it is triggered by the life cycle of the cells to which the "rogue spike proteins" attach. With an active infection, the spike attaches to ACE2 receptors on the body’s cells and the virus hijacks the cell. The immune response is to kill the cell and sometimes some surrounding cells which can cause tissue / organ damage depending on which cells get infected. Long COVID is simply tissue damage, and its symptoms totally depend on where the virus gets in the body (a great video describing this was done by Dr. John Campbell linked below).
The point is, if the “vaccine” substance gets into the bloodstream all bets are off, and it can cause all sorts of problems, depending on which cells take up the lipid nanoparticles or adenovirus vectors.
It seems as though sometimes the shots work as they were intended and the lipid nanoparticles or adenovirus mRNA carrier stays localized in the injected muscle. Not great (muscle damage and loss), but also not that bad (muscle can be rebuilt). The problem is when either of the delivery mechanisms (nanoparticles or adenovirus mRNA carrier) get into the bloodstream and circulate. There is ample evidence that this occurs quite often somehow, as documented in the substack post below (exactly why it happens still seems a bit unclear and few seem interested).
When that happens you have cells that become spike producers probably somewhere in the circulatory system, and your blood gets flooded with spike proteins that are NOT attached to a virus. When these "rogue spike" proteins (not “rogue antibodies”) then attach to ACE2 receptors everywhere, since they are not attached to a virus, they simply block an ACE2 receptor and are relatively "harmless" for the moment, though there could be some dysregulation of the renin–angiotensin–aldosterone system (RAAS).
The problems really occur when the cell that has “rogue spike proteins” bound to its ACE2 receptors reaches the end of its life cycle or is recognized to be hosting a “foreign” protein. Then it is marked for destruction by the body, and when the immune system comes to clean it up it recognizes the spike protein as foreign, and initiates an inflammatory response destroying some of the surrounding cells as well. If some of those also have spike proteins attached to their ACE2 receptors, one can imagine there is a bit of an “inflammatory cascade” generating an increasingly strong auto-immune response and likely causing severe damage to whatever tissue the cells are part of.
The damage of this “inflammatory cascade” would target places where ACE2 receptors are concentrated, thus resulting in “adverse effects” such as clotting (due to the concentration of ACE2 receptors on epithelial cells lining the blood vessels), myocarditis and heart damage (ACE2 receptors are concentrated on organ surface cells including the heart, liver, kidney), liver damage, and neurological symptoms (lots of ACE2 receptors there).
Much of “long COVID” as well as “long vax” would therefore be due not directly to the virus, but instead to the immune response which destroys not only the infected cell, but the surrounding cells as well often causing lasting damage.
The problem is that every round of shots can cause or exacerbate these issues, so none of this will stop until people stop allowing themselves to be injected with this stuff.